Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?-Reference-Cited by-同舟云学术

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

Published:2022-03-23 Issue:6 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jung Christoph¹,Kmiec Dorota²,Koepke Lennart²,Zech Fabian²,Jacob Timo¹,Sparrer Konstantin M. J.²,Kirchhoff Frank²^ORCID

Affiliation:

1. Institute of Electrochemistry, Ulm University, Ulm, Germany

2. Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany

Abstract

Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show increased transmission fitness and/or immune evasion are classified as “variants of concern” (VOCs). Recently, a SARS-CoV-2 variant first identified in November 2021 in South Africa has been recognized as a fifth VOC, termed “Omicron.” What makes this VOC so alarming is the high number of changes, especially in the viral Spike protein, and accumulating evidence for increased transmission efficiency and escape from neutralizing antibodies.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02077-21

Reference101 articles.

1. World Health Organization. 2021. Classification of Omicron (B.1.1.529): SARS-CoV-2 variant of concern. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern.

2. Viral targets for vaccines against COVID-19

3. Heavily mutated Omicron variant puts scientists on alert

4. Grabowski F Kochańczyk M Lipniacki T. 2022. The spread of SARS-CoV-2 variant Omicron with the doubling time of 2.0–3.3 days can be explained by immune evasion. medRxiv. https://www.medrxiv.org/content/10.1101/2021.12.08.21267494v2.

5. Bai Y Du Z Xu M Wang L Wu P Lau E Cowling BJ Meyers LA. 2021. International risk of SARS-CoV-2 Omicron variant importations originating in South Africa. medRxiv. https://www.medrxiv.org/content/10.1101/2021.12.07.21267410v1.

Cited by 162 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural and genomic evolutionary dynamics of Omicron variant of SARS-CoV-2 circulating in Madhya Pradesh, India;Frontiers in Medicine;2024-09-11

2. Epidemiological Features of the COVID-19 and Characteristics of Patients during the Spread of the Omicron SARS-COV-2 in Russia;Epidemiology and Vaccinal Prevention;2024-09-09

3. Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends;Viruses;2024-08-20

4. Anomalies in regional and chronological distributions of Omicron BA.1.1 lineage in the United States;2024-08-17

5. Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters;2024-07-12