Suppression of Clostridium difficile by Normal Hamster Cecal Flora and Prevention of Antibiotic-Associated Cecitis

Author:

Wilson Kenneth H.1,Silva Joseph1,Fekety F. Robert1

Affiliation:

1. Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109

Abstract

Administration of normal cecal homogenates decreased numbers of viable Clostridium difficile and prevented cecitis in antibiotic-challenged hamsters. Cecal anaerobes appeared to suppress C. difficile .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference12 articles.

1. Susceptibility of anaerobic bacteria in vitro to 23 antimicrobial agents;Bach B. T.;Chemotherapy,1980

2. Fekety R. 1979. Vancomycin p. 304-307. In G. L. Mandell et al. (ed.) Principles and practice of infectious diseases. John Wiley & Sons Inc. New York.

3. Antibiotic associated colitis: effects of antibiotics on C. difficile and the disease in hamsters;Fekety R.;Rev. Infect. Dis.,1979

4. Susceptibility of gram negative anaerobic bacilli to gentamicin and other aminoglycosides;Finegold S.;J. Infect. Dis.,1971

5. Identification of C. difficik as a cause of pseudomembranous colitis;George R. J.;Br. Med. J.,1978

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