Multiple Regulatory Mechanisms Act on the 5′ Untranslated Region of the S-Layer Gene from Thermus thermophilus HB8

Author:

Castán Pablo1,de Pedro Miguel A.1,Risco Cristina2,Vallés Cristina1,Fernández Luis A.3,Schwarz Heinz4,Berenguer José1

Affiliation:

1. Departamento and Centro de Biologı́a Molecular Severo Ochoa, CSIC—UAM,1 and

2. Departamento de Estructura de Macromoléculas2 and

3. Departamento de Biotecnologı́a Microbiana,3

4. Centro Nacional de Biotecnologı́a, CSIC Campus de Cantoblanco, Madrid 28049, Spain, and Max Plank Institut für Entwicklungsbiologie, D-72076 Tübingen, Germany4

Abstract

ABSTRACT The role of the 5′ untranslated region (5′UTR) of the S-layer gene from Thermus thermophilus was analyzed through the isolation of Δ5′UTR mutants. In these mutants the half-life of splA mRNA was strongly reduced and slpA transcription was no longer subjected to growth phase-dependent repression. Overproduction and detachment of the external envelopes of the mutants were observed in stationary phase.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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