Effect of 9-β- d -Arabinofuranosyladenine 5′-Monophosphate and 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis-Reference-Cited by-同舟云学术

Effect of 9-β- d -Arabinofuranosyladenine 5′-Monophosphate and 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis

Published:1976-12 Issue:6 Volume:10 Page:885-888
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kaufman Herbert E.¹,Varnell Emily D.¹

Affiliation:

1. Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida 32610

Abstract

Treatment of established experimental keratitis caused by herpes simplex virus with 9-β- d -arabinofuranosyladenine 5′-monophosphate (Ara-AMP) or 9-β- d -arabinofuranosylhypoxanthine 5′-monophosphate (Ara-HxMP) showed that the Ara-AMP, in a concentration of 2 or 20%, had a significant effect on the keratitis but that 0.4% Ara-HxMP showed only minimal activity. Ara-AMP was also effective in the treatment of idoxuridine-resistant keratitis. No local toxicity with a high concentration (20%) of Ara-AMP was seen, but the duration of therapy was brief.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.10.6.885

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