Affiliation:
1. Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22901
Abstract
A controlled, double-blind study was performed to compare the efficacy of two macrolide antibiotics, erythromycin and josamycin, in the therapy of
Mycoplasma pneumoniae
pneumonia. Marine Corps recruit volunteers received one of the two antibiotics in a dosage of 2 g daily for 7 days. Twelve of 21 men treated with josamycin and 9 of 25 men treated with erythromycin had confirmed
M. pneumoniae
pneumonia. The josamycin-treated group remained hospitalized for 5.4 ± 1.2 days compared to 5.1 ± 2.0 days for the erythromycin-treated group (0.60 >
P
> 0.50). Fever days were similar for the josamycin-treated (1.4 ± 0.4) and erythromycin-treated (1.2 ± 0.3) groups (
P
= 0.95). There was no difference in resolution of signs and symptoms of illness in the two study populations. Thus, josamycin is as efficacious as erythromycin in the therapy of
M. pneumoniae
pneumonia.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference15 articles.
1. Pneumonia due to Mycoplasma pneumoniae;Alexander E.R.;N. Engl. J. Med.,1966
2. Mycoplasma pneumoniae vaccine: antigenicity of buffered antigens in volunteers;Brown R.C.;Infect. Immun.,1972
3. Mycoplasma infections of man;Chanock R.M.;N. Engl. J. Med.,1965
4. Mycoplasma species identification based upon growth inhibition by specific antisera;Clyde W.A.;J. Immunol.,1964
5. Mycoplasma pneumoniae pneumonia in an urban area;Foy H.J.;J. Am. Med. Assoc.,1970
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