Comparative In Vitro Studies of Cinoxacin, Nalidixic Acid, and Oxolinic Acid-Reference-Cited by-同舟云学术

Comparative In Vitro Studies of Cinoxacin, Nalidixic Acid, and Oxolinic Acid

Published:1976-12 Issue:6 Volume:10 Page:918-920
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gordon Ralph C.¹,Stevens Lynne I.¹,Edmiston Charles E.¹,Mohan Kanwal¹

Affiliation:

1. Departments of Human Development, Medicine, and Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824

Abstract

Cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138 Shigella isolates and somewhat less active than oxolinic acid on a weight basis. Cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in Mueller-Hinton agar. Plate dilution studies of the effect of changes in agar pH on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing pH. Protein binding investigations revealed a high degree of binding, with nalidixic acid > oxolinic acid > cinoxacin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.10.6.918

Reference12 articles.

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