Quantitative Analysis of a Urine-Based Assay for Detection of Lipoarabinomannan in Patients with Tuberculosis

Author:

Shah Maunank1,Martinson Neil A.12,Chaisson Richard E.1,Martin Desmond J.3,Variava Ebrahim4,Dorman Susan E.1

Affiliation:

1. Johns Hopkins University School of Medicine, Baltimore, Maryland

2. Perinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa

3. Toga Laboratories, Johannesburg, South Africa, and Department of Medical Virology, University of Pretoria, South Africa

4. Tshepong Hospital, Northwest Department of Health, Klerksdorp, South Africa

Abstract

ABSTRACT Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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