Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption-Reference-Cited by-同舟云学术

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Giron Leila B.¹,Papasavvas Emmanouil¹,Yin Xiangfan¹,Goldman Aaron R.¹,Tang Hsin-Yao¹,Palmer Clovis S.²³,Landay Alan L.⁴,Li Jonathan Z.⁵,Koethe John R.⁶,Mounzer Karam⁷,Kostman Jay R.⁷,Liu Qin¹,Montaner Luis J.¹,Abdel-Mohsen Mohamed¹^ORCID

Affiliation:

1. The Wistar Institute, Philadelphia, Pennsylvania, USA

2. The Burnet Institute, Melbourne, Victoria, Australia

3. Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia

4. Rush University, Chicago, Illinois, USA

5. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

6. Vanderbilt University, Nashville, Tennessee, USA

7. Philadelphia FIGHT, Philadelphia, Pennsylvania, USA

Abstract

The likelihood of HIV rebound after stopping antiretroviral therapy (ART) is a combination of the size of HIV reservoirs that persist despite ART and the host immunological and inflammatory factors that control these reservoirs. Therefore, there is a need to comprehensively understand these host factors to develop a strategy to cure HIV infection and prevent viral rebound post-ART.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

amfAR, The Foundation for AIDS Research

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Institute on Aging

W. W. Smith Charitable Trust

Robert I. Jacobs Fund of the Philadelphia Foundation-the Herbert Kean, M.D., Family Professorship

Publisher

American Society for Microbiology

Subject