The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion-Reference-Cited by-同舟云学术

The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Li Xinyue¹^ORCID,Wubbolts Richard W.¹^ORCID,Bleumink-Pluym Nancy M. C.¹,van Putten Jos P. M.¹^ORCID,Strijbis Karin¹^ORCID

Affiliation:

1. Department of Biomolecular Health Sciences, Division of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands

Abstract

Bacteria can exploit membrane receptor integrins for cellular invasion, either by direct binding of bacterial adhesins or utilizing extracellular matrix components. MUC1 is a large transmembrane glycoprotein expressed by most epithelial cells that can have direct defensive or receptor functions at the host-microbe interface and is involved in facilitating integrin clustering.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03491-20

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