Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression-Reference-Cited by-同舟云学术

Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression

Published:2023-06-27 Issue:3 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Göttig Lilian¹,Weiß Christina¹,Stubbe Miona¹,Hanrieder Lisa¹²³,Hofmann Samuel¹²⁴,Grodziecki Alessandro²⁴,Stadler Daniela¹,Carpentier Arnaud⁵,Protzer Ulrike¹³⁶,Schreiner Sabrina¹²³⁴⁶^ORCID

Affiliation:

1. Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany

2. Institute of Virology, Hannover Medical School, Hannover, Germany

3. German Center for Infection Research (DZIF), Munich, Germany

4. Cluster of Excellence RESIST (Resolving Infection Susceptibility; EXC 2155), Hannover Medical School, Hannover, Germany

5. Institute of Experimental Virology, Twincore, Hannover, Germany

6. Institute of Virology, Helmholtz Zentrum München, Munich, Germany

Abstract

Our data provide a novel conceptual insight into the virus/host-cell interplay, changing the current view of how a host-cell can defeat a virus infection. Thus, our study reveals a novel and general impact of cellular Apobec3A on the intervention of human adenovirus (HAdV) gene expression and replication by improving the host antiviral defense mechanisms, thereby providing a novel basis for innovative antiviral strategies in future therapeutic settings.

Funder

Deutsche Forschungsgemeinschaft

Deutsche Krebshilfe

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03478-22

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