Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans-Reference-Cited by-同舟云学术

Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lash Emma¹,Prudent Victoria²,Stogios Peter J.³,Savchenko Alexei³⁴⁵,Noble Suzanne M.²,Robbins Nicole¹,Cowen Leah E.¹^ORCID

Affiliation:

1. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

2. Department of Microbiology and Immunology, UCSF School of Medicine, San Francisco, California, USA

3. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

4. Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

5. Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, USA

Abstract

Candida albicans is a leading human fungal pathogen that can cause life-threatening infections in immunocompromised individuals, with mortality rates of ~40%. The ability of this organism to grow in both yeast and filamentous forms is critical for the establishment of systemic infection.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03434-22

Reference47 articles.

1. Candida albicans cell-type switching and functional plasticity in the mammalian host

2. Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

3. Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

4. Invasive Candidiasis

5. Growth of Candida albicans hyphae

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