Porcine Epidemic Diarrhea Virus Antagonizes Host IFN-λ-Mediated Responses by Tilting Transcription Factor STAT1 toward Acetylation over Phosphorylation To Block Its Activation-Reference-Cited by-同舟云学术

Porcine Epidemic Diarrhea Virus Antagonizes Host IFN-λ-Mediated Responses by Tilting Transcription Factor STAT1 toward Acetylation over Phosphorylation To Block Its Activation

Published:2023-06-27 Issue:3 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Xu Jidong¹²,Gao Qin¹,Zhang Weiwu³,Zheng Jingyou¹,Chen Rong¹,Han Xiao¹^ORCID,Mao Junyong¹⁴,Shan Ying¹²,Shi Fushan¹²^ORCID,He Fang¹²^ORCID,Fang Weihuan¹²^ORCID,Li Xiaoliang¹²⁴^ORCID

Affiliation:

1. Department of Veterinary Medicine, College of Animal Sciences, Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, Zhejiang, China

2. Zhejiang Province Key Laboratory of Veterinary Medicine, MOA Key Laboratory of Animal Virology, Zhejiang University, Hangzhou, Zhejiang, China

3. Hangzhou Academy of Agricultural Sciences, Hangzhou, Zhejiang, China

4. Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya, China

Abstract

PEDV has developed sophisticated evasion mechanisms to escape host IFN signaling via its structural and nonstructural proteins. STAT1 is one of the key transcription factors in regulating expression of ISGs.

Funder

Zhejiang Provincial Key R&D Program of China

Science and Technology Innovation Leading Talents Project of ‘High-level Talents Special Support Plan’ of Zhejiang Province

Agricultural Major Technology Synergy Extension Project of Zhejiang Province

Fellowship of China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03408-22