Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice-Reference-Cited by-同舟云学术

Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Krug Stefanie¹²,Prasad Pankaj¹²,Xiao Shiqi¹²,Lun Shichun¹²,Ruiz-Bedoya Camilo A.¹³⁴,Klunk Mariah¹³,Ordonez Alvaro A.¹³⁴,Jain Sanjay K.¹³⁴^ORCID,Srikrishna Geetha¹²,Kramnik Igor⁵⁶,Bishai William R.¹²^ORCID

Affiliation:

1. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

4. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

5. The National Emerging Infectious Diseases Laboratory, Boston University School of Medicine, Boston, Massachusetts, USA

6. Department of Medicine, Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA

Abstract

Necrosis of lung lesions is a hallmark of tuberculosis (TB) that promotes bacterial growth, dissemination, and transmission. This process is driven by the persistent hyperactivation of the integrated stress response (ISR) pathway.

Funder

NIH

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03496-22

Reference51 articles.

1. World Health Organization. 2021. Global tuberculosis report 2021. World Health Organization, Geneva, Switzerland.

2. Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

3. The Immune Response in Tuberculosis