Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models-Reference-Cited by-同舟云学术

Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Langshaw Emma L.¹,Reynolds Simone¹,Ozberk Victoria¹,Dooley Jessica¹,Calcutt Ainslie¹,Zaman Mehfuz¹,Walker Mark J.²,Batzloff Michael R.¹,Davies Mark R.³^ORCID,Good Michael F.¹,Pandey Manisha¹^ORCID

Affiliation:

1. Institute for Glycomics, Griffith University, Queensland, Australia

2. Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

3. Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

Abstract

Streptococcus pyogenes is responsible for significant numbers of invasive and noninvasive infections which cause significant morbidity and mortality globally. Strep A isolates with mutations in the covR/S system display greater propensity to cause severe invasive diseases, which are responsible for more than 163,000 deaths each year.

Funder

DHAC | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03488-22

Reference46 articles.

1. The global burden of group A streptococcal diseases

2. Rheumatic fever in Indigenous Australian children

3. Global, Regional, and National Burden of Rheumatic Heart Disease, 1990–2015

4. Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB

5. Spontaneous Mutations in the CsrRS Two‐Component Regulatory System ofStreptococcus pyogenesResult in Enhanced Virulence in a Murine Model of Skin and Soft Tissue Infection

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites;Frontiers in Immunology;2024-07-19

2. Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response;Current Opinion in Infectious Diseases;2024-03-21

3. Completion of multidose vaccine series in early childhood: current challenges and opportunities;Current Opinion in Infectious Diseases;2024-03-01