An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion-Reference-Cited by-同舟云学术

An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Vaughn Bethany¹,Voth Kevin²,Price Christopher T.¹,Jones Snake¹,Ozanic Mateja³,Santic Marina³,Cygler Miroslaw²^ORCID,Abu Kwaik Yousef¹⁴

Affiliation:

1. Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA

2. Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

3. Faculty of Medicine, Department of Microbiology and Parasitology, University of Rijeka, Rijeka, Croatia

4. Center for Predictive Medicine, College of Medicine, University of Louisville, Louisville, Kentucky, USA

Abstract

Intracellular proliferation of Legionella pneumophila within a vacuole in human alveolar macrophages is essential for manifestation of Legionnaires’ pneumonia. Intravacuolar growth of the pathogen is totally dependent on remodeling the L. pneumophila -containing vacuole (LCV) by the ER and on its evasion of the endosomal-lysosomal degradation pathway.

Funder

Croatian Science Foundation

Uniri-biomed

HHS | NIH | National Institute of Allergy and Infectious Diseases

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03458-20

Reference111 articles.