Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid-Reference-Cited by-同舟云学术

Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid

Published:2020-04-23 Issue:5 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Pandey Utsav¹,Greninger Alexander L.²³,Levin Greg R.²,Jerome Keith R.²³,Anand Vikram C.⁴⁵,Dien Bard Jennifer¹⁵

Affiliation:

1. Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, California, USA

2. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA

3. Fred Hutchinson Cancer Research Institute, Seattle, Washington, USA

4. Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, California, USA

5. Keck School of Medicine at the University of Southern California, Los Angeles, California, USA

Abstract

Human herpesvirus 6 (HHV-6) is an important cause of meningitis and meningoencephalitis. As testing for HHV-6 in cerebrospinal fluid (CSF) is more readily available using the FilmArray Meningitis/Encephalitis panel (FA-ME; BioFire Diagnostics, Salt Lake City, UT), we aimed to determine the clinical significance of detecting HHV-6 in order to identify true infections and to ensure appropriate antiviral initiation. Chart review on 25 patients positive for HHV-6 by FA-ME was performed to determine clinical presentation, comorbidity, treatment, and outcome.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00313-20

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