Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia Ex Vivo : Potentials and Pitfalls-Reference-Cited by-同舟云学术

Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia Ex Vivo : Potentials and Pitfalls

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dembélé Laurent¹²³^ORCID,Franetich Jean-François¹,Soulard Valérie¹,Amanzougaghene Nadia¹,Tajeri Shahin¹,Bousema Teun⁴^ORCID,van Gemert Geert-Jan⁴,Le Grand Roger⁵,Dereuddre-Bosquet Nathalie⁵,Baird J. Kevin⁶⁷^ORCID,Mazier Dominique¹,Snounou Georges¹⁵

Affiliation:

1. Sorbonne Université, INSERM, CNRS, INSERM U1135, Centre d’Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France

2. Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali

3. Malaria Research and Training Centre (MRTC), Faculty of Pharmacy, Bamako, Mali

4. Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

5. Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematalogical and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses, France

6. Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia

7. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Abstract

For a long while, 8-aminoquinoline compounds have been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood-stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of Plasmodium cynomolgi , Plasmodium yoelii , Plasmodium berghei , and Plasmodium falciparum within several ex vivo systems—primary hepatocytes of Macaca fascicularis , primary human hepatocytes, and stably transformed human hepatocarcinoma cell line HepG2.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01416-20

Reference19 articles.

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4. Establishment of an In Vitro Assay for Assessing the Effects of Drugs on the Liver Stages of Plasmodium vivax Malaria

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