High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams-Reference-Cited by-同舟云学术

High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Djukovic Ana¹,González-Barberá Eva M.²,Sanz Jaime²³,Artacho Alejandro¹,Peñaranda Iván¹,Herrera Beatriz¹,Garzón María José¹,Salavert Miguel²,López-Hontangas José Luis²,Xavier Karina B.⁴^ORCID,Kuster Bernhard⁵,Debrauwer Laurent⁶⁷,Rolain Jean-Marc⁸,Sanz Miguel A.²³,Xavier Joao B.⁹¹⁰,Ubeda Carles¹¹¹

Affiliation:

1. Centro Superior de Investigación en Salud Pública—FISABIO, Valencia, Spain

2. Hospital Universitari i Politècnic La Fe, Valencia, Spain

3. CIBERONC, Instituto Carlos III, Madrid, Spain

4. Instituto Gulbenkian de Ciência, Oeiras, Portugal

5. Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany

6. Toxalim—Research Center in Food Toxicology, Toulouse University, INRA UMR 1331, ENVT, INP-Purpan, Paul Sabatier University, Toulouse, France

7. Axiom Platform, UMR 1331 Toxalim, MetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France

8. Aix Marseille Univ, IRD, APHM, MEPHI, IHU—Méditerranée Infection, Marseille, France

9. Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center, New York, New York, USA

10. Computational and Systems Biology Program, Sloan-Kettering Institute, New York, New York, USA

11. Centers of Biomedical Research Network (CIBER) in Epidemiology and Public Health, Madrid, Spain

Abstract

Multidrug-resistant Enterobacteriaceae (MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospitalized patients and the clinical factors that determine those levels.

Funder

Consellería de d’Educació, Investigació, Cultura i Esport

Ministerio de Economía y Competitividad

MINECO | Instituto de Salud Carlos III

Bundesministerium für Bildung und Forschung

Fundação para a Ciência e a Tecnologia

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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