Roles for Non-TATA Core Promoter Sequences in Transcription and Factor Binding-Reference-Cited by-同舟云学术

Roles for Non-TATA Core Promoter Sequences in Transcription and Factor Binding

Published:2000-05-15 Issue:10 Volume:20 Page:3608-3615
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Wolner Branden S.¹,Gralla Jay D.¹

Affiliation:

1. Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095-1569

Abstract

ABSTRACT Sequence blocks within the core region were swapped among RNA polymerase II promoters to explore effects on transcription in vitro. The pair of blocks flanking TATA strongly influenced general transcription, with an additional effect on promoter activation. These flanking elements induced a change in the ratio of activated to basal transcription, whereas swapping TATA and initiator sequences only altered general transcription levels. Swapping the flanking blocks influenced binding by general transcription factors TBP and TFIIB. The results suggest that the architecture of the extended core sequence is important in determining promoter-specific effects on both general transcription levels and the tightness of regulation.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.20.10.3608-3615.2000

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