Differential sensitivity of CD8+ suppressor and cytotoxic T lymphocyte activity to bacterial monophosphoryl lipid A-Reference-Cited by-同舟云学术

Differential sensitivity of CD8+ suppressor and cytotoxic T lymphocyte activity to bacterial monophosphoryl lipid A

Published:1991-09 Issue:9 Volume:59 Page:2994-2998
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Esquivel F¹,Taylor C E¹,Baker P J¹

Affiliation:

1. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852.

Abstract

Treatment with a preparation of monophosphoryl lipid A, known to be capable of abolishing the expression of CD8+ suppressor T cell activity generated during the antibody response to type III pneumococcal polysaccharide (SSS-III), was found to have no adverse effect upon either induction or expression of CD8+ cytotoxic T lymphocyte activity specific for influenza A virus antigens. This suggests that suppressor T cells and cytotoxic T lymphocytes represent functionally distinct subsets of CD8+ T cells which can be differentiated on the basis of their sensitivities to inactivation by monophosphoryl lipid A.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.59.9.2994-2998.1991

Reference32 articles.

1. Antigen-specific suppression of cytotoxic T cell responses in mice. I. Suppressor T cells are not cytotoxic cells;Al-Adra A. R.;Eur. J. Immunol.,1978

2. Effect of splenectomy on the expression of regulatory T cell activity;Amsbaugh D. F.;J. Immunol.,1978

3. Cytotoxic T cells in influenza infection;Askonas B. A.;Ann. N. Y. Acad. Sci.,1988

4. Homeostatic control of antibody responses: a model based on the recognition of cell-associated antibody by regulatory T cells;Baker P. J.;Transplant. Rev.,1975

5. Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived Iymphocytes;Baker P. J.;Infect. Immun.,1990

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