Susceptibility of blood-derived monocytes and macrophages to caprine arthritis-encephalitis virus

Author:

Anderson L W,Klevjer-Anderson P,Liggitt H D

Abstract

Permissiveness of blood-derived caprine monocytes to infection by caprine arthritis-encephalitis virus increased during in vitro cultivation and differentiation into macrophages, as evidenced by immunofluorescence and release of extracellular infectious virus. The degree of cell susceptibility to virus infection varied among individual goats, independent of age or breed. Caprine arthritis-encephalitis virus infection of macrophages in vitro resulted in no alteration of five characteristic functional activities.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference24 articles.

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2. Lymphocyte subpopulations of the goat: isolation and identification;Banks K. L.;Am. J. Vet. Res.,1981

3. The isolation and selected properties of blood monocytes;Bennett W. E.;J. Exp. Med.,1966

4. Isolation of mononuclear cells and granulocytes from human blood;Boyum A.;Scand. J. Clin. Lab. Invest.,1968

5. Mechanisms of immunosuppression in cytomegalovirus mononucleosis. II. Virus-monocyte interactions;Carney W. P.;J. Infect. Dis.,1981

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