Potential Mechanisms of Mucin-Enhanced Acinetobacter baumannii Virulence in the Mouse Model of Intraperitoneal Infection-Reference-Cited by-同舟云学术

Potential Mechanisms of Mucin-Enhanced Acinetobacter baumannii Virulence in the Mouse Model of Intraperitoneal Infection

Published:2019-11 Issue:11 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Harris Greg¹,Holbein Bruce E.²³,Zhou Hongyan¹,Xu H. Howard⁴,Chen Wangxue¹⁵^ORCID

Affiliation:

1. Human Health Therapeutics Research Center, National Research Council Canada, Ottawa, Ontario, Canada

2. Chelation Partners Inc., Halifax, Nova Scotia, Canada

3. Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada

4. Department of Biological Sciences, California State University, Los Angeles, Los Angeles, California, USA

5. Department of Biology, Brock University, St. Catharines, Ontario, Canada

Abstract

Porcine mucin has been commonly used to enhance the infectivity of bacterial pathogens, including Acinetobacter baumannii , in animal models, but the mechanisms for enhancement by mucin remain relatively unknown. In this study, using the mouse model of intraperitoneal (i.p.) mucin-enhanced A. baumannii infection, we characterized the kinetics of bacterial replication and dissemination and the host innate immune responses, as well as their potential contribution to mucin-enhanced bacterial virulence.

Funder

Gouvernement du Canada | National Research Council Canada

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00591-19

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