Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System-Reference-Cited by-同舟云学术

Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System

Published:2021-03-17 Issue:4 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Loh John T.¹,Shum Miranda V.¹,Jossart Scott D. R.¹,Campbell Anne M.¹,Sawhney Neha¹^ORCID,McDonald W. Hayes²³,Scholz Matthew B.⁴,McClain Mark S.¹^ORCID,Forsyth Mark H.⁵,Cover Timothy L.¹⁶⁷^ORCID

Affiliation:

1. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

2. Proteomics Laboratory, Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA

3. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

4. Vanderbilt Technologies for Advanced Genetics (VANTAGE), Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Department of Biology, The College of William and Mary, Williamsburg, Virginia, USA

6. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

7. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA

Abstract

Helicobacter pylori encounters a wide range of pH within the human stomach. In a comparison of H. pylori cultured in vitro under neutral or acidic conditions, about 15% of genes are differentially expressed, and corresponding changes are detectable for many of the encoded proteins.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00597-20

Reference91 articles.

1. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

2. Change Is Good: Variations in Common Biological Mechanisms in the Epsilonproteobacterial Genera Campylobacter and Helicobacter