Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy-Reference-Cited by-同舟云学术

Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy

Published:2020-03-24 Issue:4 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Israel Sarah¹²,Elinav Hila²,Elazary Ram³,Porat Daniel⁴,Gibori Roni⁴,Dahan Arik⁴,Azran Carmil⁵,Horwitz Ehud²⁶^ORCID

Affiliation:

1. Department of Internal Medicine, Mt. Scopus Hospital, Hebrew University Hadassah Medical Center, Jerusalem, Israel

2. Hadassah AIDS Center, Department of Clinical Microbiology and Infectious Diseases, Hebrew University Hadassah Medical Center, Jerusalem, Israel

3. Department of Surgery, Hebrew University Hadassah Medical Center, Jerusalem, Israel

4. Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

5. Clinical Pharmacy Unit, Herzliya Medical Center, Herzliya, Israel

6. Pharmacy Division, Hebrew University Hadassah Medical Center, Jerusalem, Israel

Abstract

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ∼12-fold. Several mechanistic explanations for these findings are discussed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02453-19

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