Affiliation:
1. Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands
Abstract
The
Mycobacterium tuberculosis
β-lactamase BlaC is a broad-spectrum β-lactamase that can convert a range of β-lactam antibiotics. Enzymes with low specificity are expected to exhibit active-site flexibility. To probe the motions in BlaC, we studied the dynamic behavior in solution using nuclear magnetic resonance (NMR) spectroscopy.
15
N relaxation experiments show that BlaC is mostly rigid on the pico- to nanosecond timescale.
Funder
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献