The Polyaminoisoprenyl Potentiator NV716 Revives Old Disused Antibiotics against Intracellular Forms of Infection by Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

The Polyaminoisoprenyl Potentiator NV716 Revives Old Disused Antibiotics against Intracellular Forms of Infection by Pseudomonas aeruginosa

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Gang¹,Brunel Jean-Michel²,Bolla Jean-Michel²,Van Bambeke Françoise¹^ORCID

Affiliation:

1. Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium

2. Aix Marseille Univ, INSERM, SSA, MCT, Marseille, France

Abstract

Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa , including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics.

Funder

Wallonie Bruxelles International

Fonds De La Recherche Scientifique - FNRS

Campus France

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02028-20

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