Coordination of Initiation of Nuclear Division and Initiation of Cell Division in Schizosaccharomyces pombe : Genetic Interactions of Mutations

Author:

Grallert A.1,Grallert B.1,Ribar B.1,Sipiczki M.12

Affiliation:

1. Department of Genetics1 and

2. Institute of Biology,2 University of Debrecen, Debrecen, Hungary

Abstract

ABSTRACT sep1 + encodes a Schizosaccharomyces pombe homolog of the HNF-3/forkhead family of the tissue-specific and developmental gene regulators identified in higher eukaryotes. Its mutant allele sep1-1 causes a defect in cytokinesis and confers a mycelial morphology. Here we report on genetic interactions of sep1-1 with the M-phase initiation mutations wee1 , cdc2-1w , and cdc25-22 . The double mutants sep1-1 wee1 and sep1-1 cdc2-1w form dikaryon cells at high frequency, which is due to nuclear division in the absence of cell division. The dikaryosis is reversible and suppressible by cdc25-22 . We propose that the genes wee1 + , cdc2 + , cdc25 + , and sep1 + form a regulatory link between the initiation of mitosis and the initiation of cell division.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference44 articles.

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