Affiliation:
1. Department of Genetics1 and
2. Institute of Biology,2 University of Debrecen, Debrecen, Hungary
Abstract
ABSTRACT
sep1
+
encodes a
Schizosaccharomyces pombe
homolog of the HNF-3/forkhead family of the tissue-specific and developmental gene regulators identified in higher eukaryotes. Its mutant allele
sep1-1
causes a defect in cytokinesis and confers a mycelial morphology. Here we report on genetic interactions of
sep1-1
with the M-phase initiation mutations
wee1
−
,
cdc2-1w
, and
cdc25-22
. The double mutants
sep1-1 wee1
−
and
sep1-1 cdc2-1w
form dikaryon cells at high frequency, which is due to nuclear division in the absence of cell division. The dikaryosis is reversible and suppressible by
cdc25-22
. We propose that the genes
wee1
+
,
cdc2
+
,
cdc25
+
, and
sep1
+
form a regulatory link between the initiation of mitosis and the initiation of cell division.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
24 articles.
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