A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens-Reference-Cited by-同舟云学术

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens

Published:2018-05 Issue:5 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lin Yu-Wei¹,Chen Ke¹,Wang Jiping¹,Velkov Tony²,Zhou Qi Tony³,Li Jian¹

Affiliation:

1. Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

2. Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, Victoria, Australia

3. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA

Abstract

ABSTRACT The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log 10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (<1-log 10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02527-17

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