Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1-Reference-Cited by-同舟云学术

Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yato Keigo¹²,Onodera Taishi³,Matsuda Mami¹,Moriyama Saya³,Fujimoto Akira¹,Watashi Koichi¹,Aizaki Hideki¹^ORCID,Tanaka Tomohisa⁴,Moriishi Kohji⁴^ORCID,Nishitsuji Hironori⁵,Shimotohno Kunitada⁶,Tamura Koji²,Takahashi Yoshimasa³,Wakita Takaji¹,Muramatsu Masamichi¹,Kato Takanobu¹,Suzuki Ryosuke¹²^ORCID

Affiliation:

1. Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

2. Department of Biological Science and Technology, Tokyo University of Science, Tokyo, Japan

3. Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan

4. Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu, Japan

5. Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Japan

6. Genome Medical Sciences Project, National Center for Global Health and Medicine, Tokyo, Japan

Abstract

The HBV preS1 amino acid 2 to 47 region (preS1/2–47) is essential for virus binding to sodium taurocholate cotransporting polypeptide. Several MAbs targeting preS1/2–47 have been reported to neutralize HBV infection; however, which region in preS1/2–47 contains the critical neutralizing epitope(s) for HBV infection is unclear.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01680-20

Reference44 articles.

1. World Health Organization. 2019. Hepatitis B. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b. Accessed 1 May 2020.

2. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

3. Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus