A Heterologous Challenge Rescues the Attenuated Immunogenicity of SARS-CoV-2 Omicron BA.1 Variant in Syrian Hamster Model

Author:

Ma Jian1,Liu Xuan1,Zhou Ming1,Chen Peiwen234,Chen Rirong234,Wang Jia234,Zhu Huachen234,Wu Kun1,Ye Jianghui1,Zhang Yali1,Yuan Quan1,Tang Qiyi5ORCID,Yuan Lunzhi1ORCID,Cheng Tong1,Guan Yi234,Xia Ningshao1

Affiliation:

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China

2. State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

3. Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, China

4. EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, China

5. Department of Microbiology, Howard University College of Medicine, Washington, DC, USA

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant causes breakthrough infections among convalescent patients and vaccinated populations. However, Omicron does not generate robust cross-protective responses.

Funder

National Science Key Research and Devlopment Project

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Production, Education and Research Project of Xiamen

Natural Science Foundation of Guangdong Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Live attenuated COVID-19 vaccines: approaches to development and prospects for clinical use;Journal of microbiology, epidemiology and immunobiology;2023-07-11

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