Synergy Between Cephalosporin and Aminoglycoside Antibiotics Against Providencia and Proteus-Reference-Cited by-同舟云学术

Synergy Between Cephalosporin and Aminoglycoside Antibiotics Against Providencia and Proteus

Published:1974-06 Issue:6 Volume:5 Page:571-577
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hyams Phineas J.¹,Simberkoff Michael S.¹,Rahal James J.¹

Affiliation:

1. Infectious Disease Division, New York Veterans Administration Hospital and Department of Medicine, New York University School of Medicine, New York, New York 10010

Abstract

Clinical isolates of Providencia and Proteus with relative aminoglycoside resistance were tested for susceptibility to combinations of gentamicin or tobramycin with cephalothin or cefazolin. The minimal bactericidal concentration of aminoglycoside for one-third of the strains was reduced by fourfold or more in the presence of one-fourth of the minimal bactericidal concentration of either cephalosporin. This effect was achieved by clinically attainable concentrations of cephalothin or cefazolin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.5.6.571

Reference17 articles.

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