Failure of Micro Media FOX Microdilution System to detect decreased susceptibility of Streptococcus pneumoniae to penicillin

Author:

Carroll K1,Cohen S1,Saxon B1,Hamilton L1

Affiliation:

1. Department of Pathology, University of Utah Medical Center, Salt Lake City 84132.

Abstract

Twelve isolates of Streptococcus pneumoniae with decreased susceptibility by oxacillin screen were susceptible by the FOX panel (Micro Media Systems, Cleveland, Ohio), a commercial microdilution system designed for fastidious organisms. These organisms were found to be moderately susceptible or resistant by broth macrodilution and agar dilution methods. This discrepancy indicates that the FOX panel is not reliable for susceptibility testing of S. pneumoniae.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference6 articles.

1. Jorgensen J. H. C. Corlett-Knapp G. V. Doern et al. 1991. Multicenter comparison of the use of Haemophilus test medium for broth dilution susceptibility testing of Streptococcus pneumoniae abstr. C-164 p. 369. Abstr. 91st Gen. Meet. Am. Soc. Microbiol. 1991.

2. Pneumococcal resistance to antibiotics;Klugman K. P.;Clin. Microbiol. Rev.,1990

3. National Committee for Clinical Laboratory Standards. 1990. Performance standards for antimicrobial disk susceptibility tests vol. 10 no. 7. National Committee for Clinical Laboratory Standards Villanova Pa.

4. National Committee for Clinical Laboratory Standards. 1990. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A2. National Committee for Clinical Laboratory Standards Villanova Pa.

5. False susceptible penicillin G MICs for Streptococcus pneumoniae with a commercial microdilution system;Shanholtzer C. J.;Am. J. Clin. Pathol.,1986

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