A Novel Point Mutation in the N Gene of SARS-CoV-2 May Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR
Author:
Affiliation:
1. Sidra Medicine, Doha, Qatar
2. Weill Cornell Medicine–Qatar, Doha, Qatar
Publisher
American Society for Microbiology
Subject
Microbiology (medical)
Link
https://journals.asm.org/doi/pdf/10.1128/JCM.03278-20
Reference5 articles.
1. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
2. Mutations on COVID-19 diagnostic targets
3. A Recurrent Mutation at Position 26340 of SARS-CoV-2 Is Associated with Failure of the E Gene Quantitative Reverse Transcription-PCR Utilized in a Commercial Dual-Target Diagnostic Assay
4. SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene
5. Identification of a Polymorphism in the N Gene of SARS-CoV-2 That Adversely Impacts Detection by Reverse Transcription-PCR
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