A Functionally Distinct TATA Box Required for Late Progression through the Epstein-Barr Virus Life Cycle-Reference-Cited by-同舟云学术

A Functionally Distinct TATA Box Required for Late Progression through the Epstein-Barr Virus Life Cycle

Published:1998-10 Issue:10 Volume:72 Page:8338-8343
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Serio Tricia R.¹,Cahill Niamh¹,Prout Matthew E.¹,Miller George¹²³

Affiliation:

1. Department of Molecular Biophysics and Biochemistry,1

2. Department of Epidemiology and Public Health,2 and

3. Department of Pediatric Infectious Diseases3 Yale University, New Haven, Connecticut 06520

Abstract

ABSTRACT During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3′ flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.10.8338-8343.1998

Reference49 articles.

1. DNA sequence and expression of the B95-8 Epstein-Barr virus genome;Baer R.;Nature,1984

2. Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells

3. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences;Bucher P.;J. Mol. Biol.,1990

4. Activation of expression of latent Epstein-Barr virus after gene transfer with a small cloned subfragment of heterogeneous viral DNA;Countryman J.;Proc. Natl. Acad. Sci. USA,1985

5. Mechanism of inhibition of Epstein-Barr virus replication by phosphonoformic acid;Datta A. K.;Virology,1981

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Viral reprogramming of host transcription initiation;Nucleic Acids Research;2024-03-12

2. Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses;Seminars in Cell & Developmental Biology;2023-09

3. Replication Compartments—The Great Survival Strategy for Epstein–Barr Virus Lytic Replication;Microorganisms;2022-04-25

4. A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains;PLOS Pathogens;2022-01-18

5. A Two-tiered Functional Screen Identifies Herpesviral Transcriptional Modifiers and their Essential Domains;2021-09-22