Protection of Mice against Lethal Coxsackievirus B3 Infection by Using DNA Immunization-Reference-Cited by-同舟云学术

Protection of Mice against Lethal Coxsackievirus B3 Infection by Using DNA Immunization

Published:1998-10 Issue:10 Volume:72 Page:8327-8331
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Henke Andreas¹,Wagner Elke¹,Whitton J. Lindsay²,Zell Roland¹,Stelzner Axel¹

Affiliation:

1. Institute of Virology, Medical Center, Friedrich Schiller University, 07745 Jena, Germany,1 and

2. Department of Neuropharmacology, CVN-9, The Scripps Research Institute, La Jolla, California 920372

Abstract

ABSTRACT Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.10.8327-8331.1998

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