Characteristics of Human Antibody to Diphtheria Toxin-Reference-Cited by-同舟云学术

Characteristics of Human Antibody to Diphtheria Toxin

Published:1973-02 Issue:2 Volume:7 Page:130-136
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bazaral M.¹,Goscienski P. J.¹,Hamburger R. N.¹

Affiliation:

1. Department of Pediatrics, Immunology and Allergy Division, University of California, San Diego, La Jolla, California 92037

Abstract

Human antibody to diphtheria toxin was analyzed with an ammonium sulfate radioimmunoassay. In 15 immune sera with titers of between 0.03 and 25 units/ml, the avidity was similar to that of U.S. standard antitoxin. The proportion of the post-immunization anti-diphtheria antibody specific for fragment A was variable, but in the 10 sera tested constituted a substantial fraction of the antibody. Approximately 2% of healthy adult males tested failed to make an antidiphtheria toxin response after two booster doses of 1.5 Lf adsorbed diphtheriatetanus toxoid, although these nonresponders made precipitating antibody to tetanus toxoid and had normal immunoglobulin levels.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.7.2.130-136.1973

Reference13 articles.

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2. Structure and activity of diphtheria toxin H;Drazin R.;J. Biol. Chem.,1971

3. Combined tetanus-diphtheria immunization of adults: use of small doses of diphtheria toxoid;Edsall G.;Amer. J. Pub. Health,1954

4. A quantitative immunochemical measure of the pritnary interaction between I* BSA and antibody;Farr R. S.;J. Infect. Dis.,1958

5. Observations on the structure of diphtheria toxin I;Gill M. D.;J. Biol. Chem.,1971

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