Transfer of Streptomycin Biosynthesis Gene Clusters within Streptomycetes Isolated from Soil

Author:

Egan Sharon1,Wiener Pamela1,Kallifidas Dimitrios1,Wellington Elizabeth M. H.1

Affiliation:

1. Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL

Abstract

ABSTRACT Streptomyces strains isolated from soil were found to possess various numbers of genes from the streptomycin biosynthesis cluster. The strains missing genes from the cluster also lacked the ability to produce streptomycin. Two of the isolates which contain only part of the cluster are apparently recipients of a gene transfer event. The implications for the role of gene transfer in antibiotic evolution are discussed.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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