Affiliation:
1. IRIS, Chiron Vaccines, 53100 Siena, Italy
Abstract
ABSTRACT
The vacuolating cytotoxin of
Helicobacter pylori
, VacA, enters the cytoplasm of target cells and causes vacuolar degeneration by interfering with late stages of endocytosis. By using indirect immunofluorescence and flow cytometry, we have demonstrated that VacA binds to specific high-affinity cell surface receptors and that this interaction is necessary for cell intoxication.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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