The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients
Author:
Affiliation:
1. Servizio di Virologia, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy,1 and
2. Department of Virology, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 277092
Abstract
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Link
https://journals.asm.org/doi/pdf/10.1128/AAC.42.2.444
Reference25 articles.
1. Four dually resistant human cytomegalovirus strains from AIDS patients: single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively.;Baldanti F.;Scand. J. Infect. Dis. Suppl.,1995
2. A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate
3. Baldanti F. M. Boeckh S. Chou C. Crumpacker S. Danner W. L. Drew D. Emanuel A. Erice W. D. Hardy and S. Spector. 1996. Drug resistance in cytomegalovirus: current knowledge and implications for patient management. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 12 (Suppl. 1) : S1–S22.
4. Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS
5. Alpha-, beta- and gamma herpesviruses encode a putative phosphotranspherase.;Chee M. S.;J. Gen. Virol.,1989
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