Therapeutic Effect of Diminazene Aceturate on Parasitic Blood Fluke Schistosoma mansoni Infection-Reference-Cited by-同舟云学术

Therapeutic Effect of Diminazene Aceturate on Parasitic Blood Fluke Schistosoma mansoni Infection

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

de Brito Mariana G.¹,Mengarda Ana C.¹,Oliveira George L.²,Cirino Maria E.¹,Silva Tais C.¹,de Oliveira Rosimeire N.³,Allegretti Silmara M.⁴,de Moraes Josué¹^ORCID

Affiliation:

1. Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, São Paulo, Brazil

2. Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso, Campus Avançado de Guarantã do Norte, Guarantã do Norte, Mato Grosso, Brazil

3. Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brazil

4. Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

Abstract

Praziquantel is currently the only drug available to treat schistosomiasis, a disease of enormous public health significance caused by a blood fluke of the genus Schistosoma . Diminazene, a drug approved by the FDA, has been successfully used to treat diseases caused by blood protozoan parasites. In this study, we evaluated the antiparasitic properties of diminazene against Schistosoma mansoni ex vivo and in mice harboring either chronic or early S. mansoni infections.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01372-20

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