Affiliation:
1. Department of Microbiology
2. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia 22908
Abstract
SUMMARY
All humans are continuously exposed to inhaled
Aspergillus
conidia, yet healthy hosts clear the organism without developing disease and without the development of antibody- or cell-mediated acquired immunity to this organism. This suggests that for most healthy humans, innate immunity is sufficient to clear the organism. A failure of these defenses results in a uniquely diverse set of illnesses caused by
Aspergillus
species, which includes diseases caused by the colonization of the respiratory tract, invasive infection, and hypersensitivity. A key concept in immune responses to
Aspergillus
species is that the susceptibilities of the host determine the morphological form, antigenic structure, and physical location of the fungus. In this review, we summarize the current literature on the multiple layers of innate defenses against
Aspergillus
species that dictate the outcome of this host-microbe interaction.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Cited by
175 articles.
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