Affiliation:
1. Hubrecht Laboratory and the University of Utrecht, Utrecht, the Netherlands
2. Department of Biology, Princeton University, Princeton, New Jersey 08540
Abstract
Adenosine-3′,5′-cyclic monophosphate was shown to be the compound found in
Escherichia coli
responsible for the attraction of the amoebae of the cellular slime mold
Dictyostelium discoideum
. A number of other nucleotides were tested and the following were active: tubercidin-3′,5′-cyclic monophosphate, N
6
-2′-
O
-dibutyryl-adenosine-3′,5′-cyclic monophosphate, 5′-methylene adenosine-3′,5′-cyclic monophosphonate, guanosine-3′,5′-cyclic monophosphate, uridine-3′,5′-cyclic monophosphate, cytidine-3′,5′-cyclic monophosphate, inosine-3′,5′-cyclic monophosphate, and thymidine-3′,5′-cyclic monophosphate. They were less active than adenosine-3′,5′-cyclic monophosphate. It is suggested that cyclic adenosine monophosphate secreted by the bacteria is used by the amoebae as a means of sensing and orienting towards food.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
84 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献