Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55 -Dependent Mechanism-Reference-Cited by-同舟云学术

Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55 -Dependent Mechanism

Published:2020-05-28 Issue:12 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Matmati Nabil¹²³,Hassan Bachar H.¹²,Ren Jihui¹²,Shamssedine Ashraf A.¹²,Jeong Eunmi¹²,Shariff Baasil¹²,Snider Justin¹²,Rødkær Steven V.⁴,Chen Guocai⁵,Mohanty Bidyut K.⁶,Zheng W. Jim⁵,Obeid Lina M.¹²⁷,Røssel-Larsen Martin⁴,Færgeman Nils J.⁴,Hannun Yusuf A.¹²⁶

Affiliation:

1. The Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA

2. Department of Medicine, Stony Brook University, Stony Brook, New York, USA

3. Department of Neurology, Rochester Regional Health, Rochester, New York, USA

4. Villum Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

5. School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA

6. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA

7. Northport Veterans Affairs Medical Center, Northport, New York, USA

Abstract

Defects in the spindle assembly checkpoint (SAC) can lead to aneuploidy and cancer. Sphingolipids have important roles in many cellular functions, including cell cycle regulation and apoptosis. However, the specific mechanisms and functions of sphingolipids in cell cycle regulation have not been elucidated. Using analysis of concordance for synthetic lethality for the yeast sphingolipid phospholipase ISC1 , we identified two groups of genes. The first comprises genes involved in chromosome segregation and stability ( CSM3 , CTF4 , YKE2 , DCC1 , and GIM4 ) as synthetically lethal with ISC1 .

Funder

HHS | National Institutes of Health

Cancer Prevention and Research Institute of Texas

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00340-19

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