Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner

Author:

Chen Meng1,Wang Meng-Hang1,Shen Xue-Gang1,Liu Hao2,Zhang Yu-Yuan1,Peng Jin-Mei1,Meng Fandan1,Wang Tong-Yun1,Bai Yuan-Zhe1,Sun Ming-Xia1,Tian Zhi-Jun1,Yin Xin1,Cai Xue-Hui13,Tang Yan-Dong13ORCID

Affiliation:

1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China

2. School of Life Sciences and Engineering, Foshan University, Foshan, Guangdong Province, China

3. Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin, China

Abstract

Recent studies have shown accelerated PRV cross-species spillover and that PRV poses a potential threat to humans. PRV infection in humans always manifests as a high fever, tonic-clonic seizures, and encephalitis.

Funder

CAAS | HVRI, CAAS | State Key Laboratory of Veterinary Biotechnology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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