Effect of malnutrition on serum and milk antibodies in Zairian women

Author:

Brüssow H1,Barclay D1,Sidoti J1,Rey S1,Blondel A1,Dirren H1,Verwilghen A M1,Van Geert C1

Affiliation:

1. Nestlé Research Center, Nestec Ltd., Lausanne, Switzerland.

Abstract

Serum and human milk antimicrobial antibody titers were measured longitudinally in 17 malnourished and 14 control Zairian women during 6 to 18 months of lactation to test whether malnutrition is specifically associated with an impaired secretory antibody response. No decreases in total serum and human milk immunoglobulin concentrations, neutralizing antibody titers against rotavirus, or specific enzyme-linked immunosorbent assay antibody titers against rotavirus, respiratory syncytial virus, Escherichia coli, Streptococcus pneumoniae, and Haemophilus influenzae were detected when malnourished women were compared with control women. Malnutrition had no effect on circulating and secretory antibody concentrations in Zairian women. Daily human milk outputs, however, were about 30% lower in malnourished than in control women, resulting in a correspondingly lower ingestion of immunoglobulins by the children of malnourished women.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Reference30 articles.

1. Barclay D. A. Blondel A.-M. Verwilghen C. Van Geert and H. Dirren. Unpublished data.

2. Dietary intake measurement in rural Zaire: macronutrients;Barclay D.;Nutr. Res.,1993

3. Barclay D. 1989. Influence de l'etat nutritionnel de la mère sur l'allaitement au sein et sur la croissance de l'enfant en milieu rural au Zaire. Doctoral thesis. University of Nancy Nancy France.

4. Seroprevalence of immunoglobulin M (IgM) and IgG antibodies to polysaccharides of Streptococcus pneumoniae in different age groups of Ecuadorian and German children;Brüssow H.;J. Clin. Microbiol.,1992

5. Rotavirus-inhibitory activity in serial milk samples from Mexican women and rotavirus infections in their children during their first year of life;Brüssow H.;J. Clin. Microbiol.,1993

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