Affiliation:
1. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523
Abstract
ABSTRACT
A novel subclass of quinolones, 2-pyridones, showed potent activity against
Mycobacterium tuberculosis
, with KRQ-10018 being an early lead. KRQ-10018 showed better activity in vitro against
M. tuberculosis
versus moxifloxacin. In vivo efficacy of KRQ-10018 at 300 mg/kg of body weight was similar to that of isoniazid at 25 mg/kg, but showed less activity than moxifloxacin at 300 mg/kg.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
25 articles.
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