Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure-Reference-Cited by-同舟云学术

Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Witmer Kathrin¹,Dahalan Farah A.¹,Delves Michael J.²,Yahiya Sabrina¹,Watson Oliver J.³,Straschil Ursula¹,Chiwcharoen Darunee⁴,Sornboon Boodtee⁴,Pukrittayakamee Sasithon⁴⁵,Pearson Richard D.⁶,Howick Virginia M.⁶,Lawniczak Mara K. N.⁶,White Nicholas J.⁴⁷,Dondorp Arjen M.⁴⁵⁷,Okell Lucy C.³,Chotivanich Kesinee⁴⁵,Ruecker Andrea⁴⁷^ORCID,Baum Jake¹^ORCID

Affiliation:

1. Department of Life Sciences, Imperial College London, London, United Kingdom

2. London School of Hygiene and Tropical Medicine, London, United Kingdom

3. Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

4. Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

5. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

6. Wellcome Sanger Institute, Hinxton, United Kingdom

7. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Abstract

Resistance to artemisinin-based combination therapy (ACT) in the Plasmodium falciparum parasite is threatening to reverse recent gains in reducing global deaths from malaria. While resistance manifests as delayed parasite clearance in patients, the phenotype can only spread geographically via the sexual stages and mosquito transmission. In addition to their asexual killing properties, artemisinin and its derivatives sterilize sexual male gametocytes. Whether resistant parasites overcome this sterilizing effect has not, however, been fully tested.

Funder

Medicines for Malaria Venture

UKRI | Engineering and Physical Sciences Research Council

UKRI | Medical Research Council

Wellcome

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00898-20

Reference58 articles.