Reassessment of Recommended Imipenem Doses in Febrile Neutropenic Patients with Hematological Malignancies-Reference-Cited by-同舟云学术

Reassessment of Recommended Imipenem Doses in Febrile Neutropenic Patients with Hematological Malignancies

Published:2009-02 Issue:2 Volume:53 Page:785-787
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lamoth F.¹,Buclin T.²,Csajka C.²,Pascual A.¹,Calandra T.¹,Marchetti O.¹

Affiliation:

1. Infectious Diseases Service

2. Division of Clinical Pharmacology and Toxicology, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

Abstract

ABSTRACT Imipenem plasma concentrations were analyzed in 57 febrile neutropenic patients using the NONMEM program. The recommended 2-g/day regimen achieved coverage of the most common bacteria (MIC 90 = 1 mg/liter) during the whole dosing interval in only 53% of patients. This goal was achieved in 90% of patients with 3 g/day.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00891-08

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