Th2 Responses Predominate during the Early Phases of Infection in Patients with Localized Cutaneous Leishmaniasis and Precede the Development of Th1 Responses-Reference-Cited by-同舟云学术

Th2 Responses Predominate during the Early Phases of Infection in Patients with Localized Cutaneous Leishmaniasis and Precede the Development of Th1 Responses

Published:2003-04 Issue:4 Volume:71 Page:2244-2246
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bourreau Eliane¹,Gardon Jacques²,Pradinaud Roger³,Pascalis Hervé¹⁴,Prévot-Linguet Ghislaine¹⁴,Kariminia Amina¹,Pascal Launois¹

Affiliation:

1. Immunologie des Leishmanioses

2. Service d'Epidémiologie, Institut Pasteur

3. Institut Guyanais de Dermatologie Tropicale, E.A. 2188, Centre Hospitalier Andrée Rosemon

4. Institut d'Enseignement Supérieur de la Guyane, Université Antilles-Guyane, Cayenne, French Guiana

Abstract

ABSTRACT Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis . Although the number of parasites increased in Th2 lesions, no correlation was found between the levels of cytokine expression and the number of parasites. In contrast, the decreased number of parasites in Th1 lesions is negatively correlated to gamma interferon expression.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.4.2244-2246.2003

Reference16 articles.

1. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature383:787-793.

2. Biedermann, T., S. Zimmermann, H. Himmelrich, A. Gumy, O. Egeter, A. K. Sakrauski, I. Seemüller, H. Voigt, P. Launois, A. D. Levine, H. Wagner, K. Heeg, J. A. Louis, and M. Röcken. 2001. IL-4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol.2:1054-1060.

3. Bourreau, E., G. Prévot, R. Pradinaud, and P. Launois. 2001. Interleukin(IL)-13 is the predominant Th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12. J. Infect. Dis.158:953-959.

4. Caceres-Dittmar, G., F. J. Tapia, M. A. Sanchez, M. Yamuara, K. Uyemera, R. L. Modlin, B. R. Bloom, and J. Convit. 1993. Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction. Clin. Exp. Immunol.91:500-505.

5. Chico, M. E., R. H. Guderian, P. J. Cooper, R. Armijos, and M. Grogl. 1995. Evaluation of a direct immunofluorescent antibody (DIMA) test using Leishmania genus-specific monoclonal antibody in the routine diagnosis of cutaneous leishmaniasis. Rev. Soc. Bras. Med. Trop.28:99-103.

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