In vitro activity of the trinem sanfetrinem (GV104326) against gram-positive organisms

Author:

Singh K V1,Coque T M1,Murray B E1

Affiliation:

1. Department of Internal Medicine, University of Texas Medical School, Houston 77030, USA.

Abstract

The in vitro activity of the trinem sanfetrinem (formerly GV104326) (GV) was compared with that of vancomycin, ampicillin, and/or nafcillin against 287 gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and multiresistant enterococci, by the agar and microbroth dilution methods. GV demonstrated 2 to 16 times more activity than ampicillin and nafcillin against the majority of these organisms. The MIC range of GV was 16 to 64 micrograms/ml for 19 Enterococcus faecium strains that were highly resistant to ampicillin (ampicillin MIC range, 64 to 512 micrograms/ml) and vancomycin resistant and 0.25 to 32 micrograms/ml for resistant Rhodococcus spp. Similar activities (+/-1 dilution) were observed by either the agar or the broth microdilution method. GV demonstrated bactericidal activity against a beta-lactamase-producing Enterococcus faecalis strain and against two methicillin-susceptible Staphylococcus aureus strains in 10(5)-CFU/ml inocula. Synergy between GV and gentamicin was observed against an E. faecalis strain that lacked high-level gentamicin resistance. The activity of GV suggests this compound warrants further study.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference37 articles.

1. Arduino R. C. and B. E. Murray. 1993. Enterococcus: antimicrobial resistance p. 3-15. In G. L. Mandell R. G. Douglas and J. E. Bennett (ed.) Principles and practice of infectious diseases vol. 2. Churchill Livingstone Inc. New York.

2. Characterization of ~-lactamases;Bush K.;Antimicrob. Agents Chemother.,1989

3. Vancomycin-resistant streptococci or Leuconostoc spp;Buu-Hoi A.;Antimicrob. Agents Chemother.,1985

4. Vancomycin-resistant leuconostocs, lactobacilli and now pediococci;Colman G.;J. Hosp. Infect.,1987

5. Meningitis caused by vancomycin-resistant Leuconostoc sp;Coovadia Y. M.;J. Clin. Microbiol.,1987

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